Chronic Kidney Disease Epidemic in Central America: Urgent Public Health Action Is Needed amid Causal Uncertainty

The 52nd Directing Council of the Pan American Health Organization (PAHO), in response to a call for action of the Minister of Health of El Salvador, recognized chronic kidney disease from nontraditional causes (CKDnT) affecting agricultural communities in Central America as a serious public health problem that requires urgent, effective, and concerted multisectoral action [1]. Most Central American countries do not have surveillance systems capable of detecting chronic kidney disease (CKD). However, many reports [2–4] and data from PAHO show the epidemiological magnitude of the disease. A proxy for CKDnT mortality, the age standardized mortality rate due to chronic kidney disease—coded as N18 (CKD-N18) by the 2010 International Classification of Diseases—is notably higher for men and women in Nicaragua and El Salvador compared to other countries in the region and has been since at least 2000 (http:// www.paho.org/hq/index.php?option = com _content&view = article&id = 9402). CKDN18 data also show disproportionate mortality from the disease in males compared to females (Figure 1). Mortality due to CKD in El Salvador and Nicaragua exhibited a pattern of excess mortality in young adults (Figure 2), which is consistent with many other clinical and epidemiological reports [2–4]. CKDnT has been largely reported in some clustered farming communities traditionally burdened by socioeconomic disadvantages from northern Nicaragua [2], the Pacific coast of El Salvador [3], and other countries such as Costa Rica, Guatemala, Honduras, and the south of Mexico [4]. The disease affects mostly young adult male agricultural workers, e.g., sugarcane cutters. CKDnT has also been described in agricultural workers in Sri Lanka and India [5–6]. Studies reveal that patients affected by CKDnT show a clinical and pathologic pattern of a tubule-interstitial disease [7– 8], which seems to progress to end-stage renal disease in a relatively short time. This clinical pattern explains at least in part the high burden imposed on the affected countries for the delivery of health services. For example, a 50% increase in hospitalizations for CKD from 2005 to 2012 was reported in El Salvador, making CKD the leading cause of death in El Salvador’s main hospital [1]. CKDnT is a chronic and multifactorial condition that has been neglected for quite some time. The causes of this epidemic have not been elucidated yet. Several potential etiological factors have been considered [7]. Given the disease’s higher prevalence in agricultural communities and its clinical and epidemiological characteristics, which are similar to CKDnT in Sri Lanka [5], it is reasonable to draw attention to two interdependent factors: the misuse of agrochemicals and the working conditions of the labor force. The misuse of pesticides has been widespread in Central America for a long time [9]. This region imported 33 million kg of active ingredient per year with an increase of 33% during 2000–2004. From a total of 403 pesticides (13 of which constitute 77% of the total pesticides that were imported), 22% were highly/extremely acutely toxic, 33% were moderately/severely irritating or sensitizing, and 30% had multiple chronic toxicities. Out of 41 banned or highly regulated pesticides as per international treaties, 16 were imported to Central America, four of which are among the 13 most imported pesticides [10]. Although the specific mechanisms to explain the nephrotoxicity of some pesticides are still under investigation, the nephrotoxicity of several of them is already known [11,12]. Harsh working conditions, especially regular exposure to very hot temperatures and extreme physical effort, lead to heat stress and dehydration. Along with exposure to pesticides, these seem to play an important role in the occurrence of the disease, particularly among sugarcane cutters [13]. The weakness of regulatory systems [10], along with the agriculture dependency of local economies [14] and cultural agricultural practices [9], contribute to poor compliance with international safety and health standards for the use of agrochemicals and for occupational hygiene. Many questions related to these potential causative agents remain unanswered. For example, why is there such an important difference in the distribution of CKD between countries? Are there differences in the agricultural practices and work processes in areas with the same climatic characteristics and devoted to the same type of plantations (e.g., sugarcane)? Which types of agrochemicals have been used in the affected areas? How do we explain cases in nonsugarcane cutters, as well as in women? Other hypothesized causal agents merit further investigation. Nonsteroidal